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Table 5 Clearance of amikacin and creatinine by CVVHDF and summary of CVVHDF conditions

From: An open prospective study of amikacin pharmacokinetics in critically ill patients during treatment with continuous venovenous haemodiafiltration

Patient profile

ClCVVHDF (l h-1)

FCVVHDF

CrCl (l h-1)

Actual effluent flow rate (l h-1)

Number. of filters ^

Age of filter* (h)

P1C

2.53

0.98

2.19

3.16

1

16

P2D

2.55

0.94

2.70

2.91

1

27

P3A

3.40

0.87

3.20

4.10

1

1

P5B

2.97

0.80

2.86

3.95

1

26

Mean

2.86

0.90

2.74

3.53

1

-

+/−

+/−

+/−

+/−

+/−

  

s.d.

0.412

0.08

0.42

0.584

  
  1. *At start of dosage interval.
  2. ^ During dosage interval.
  3. PX (1–5) patients 1–5. ClCVVHDF: clearance via CVVHDF FCVVHDF: Fraction of total body clearance via CVVHDF. CrCl: Creatinine clearance.