Figure 5
α-BGT and DHβE pharmacological effects on isolated beating-heart preparations. The nicotinic antagonists α-BGT (panels A and B) and DHβE (panels C and D) were perfused in the absence (black circles) or presence (open squares) of 10 μM nicotine in healthy (panels A and C) and chagasic (panel B and D) hearts. Observe that α-BGT or DHβE, in healthy hearts, induced a significant bradycardia that counteracted the nicotine effect. p < 0.05 indicates statistically significant difference between drug’s group (*) or to the basal heart rate (·).