Figure 1

Aortic DHE fluorescence Effects of sGC activator BAY 60-2770 and sGC stimulator BAY 41-8543 in vivo treatment on oxidative stress parameters in tolerant rats. Quantification of vascular ROS formation in aortic cryo-sections was assessed by fluorescent microtopography using the superoxide-sensitive dye DHE (1 µM).

The data are the means ± SEM from 3-4 animals/group. *, p<0.05 vs. control; ^#, p<0.05 vs. GTN; ^$, p<0.05 vs. BAY 60-2770; ^, p<0.05 vs. low dose treatment.