Skip to main content
Fig. 7 | BMC Pharmacology and Toxicology

Fig. 7

From: Thiram, an inhibitor of 11ß-hydroxysteroid dehydrogenase type 2, enhances the inhibitory effects of hydrocortisone in the treatment of osteosarcoma through Wnt/β-catenin pathway

Fig. 7

Effect of si-11HSD2 combined with HC on osteosarcoma cells. A The 11HSD2 expression level was determined by reverse transcription-quantitative PCR and WB in MG63 and Saos-2 cells. B Effect of drugs on the viability of human osteosarcoma cells: Left: Mg63, right: Saos-2. C Effect of drugs on the migration of Mg63 cells. D Effect of drugs on the migration of Saos-2 cells. E The combination of HC and siRNA increased apoptosis in osteosarcoma cells. F The combination of HC and siRNA increased cell arrest in osteosarcoma cells. G The levels of cortisol and cortisone in osteosarcoma cells after treatment with HC and/or si-11HSD2. H HC and/or siRNA affected the expression of proteins in Wnt/β-catenin pathway in Saos-2 cells. I HC and/or siRNA affect the proteins in Wnt/β-catenin pathway in Mg63 cells

Back to article page

BMC Pharmacology and Toxicology

ISSN: 2050-6511

Contact us