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Fig. 8 | BMC Pharmacology and Toxicology

Fig. 8

From: Pharmacokinetic/Pharmacodynamic modelling of Saxagliptin and its active metabolite, 5-hydroxy Saxagliptin in rats with Type 2 Diabetes Mellitus

Fig. 8

(a) Calculated SAX DPP-4 inhibition ratios versus predicted values. The linear line is red and the OV vs. PRE points are black solid square. (b) PD profiles of parent SAX in T2DM rats following a intragastric dose of 10 mg/kg. The blue solid points represent calculated individual DPP-4 inhibition ratios (n=3). The red solid line represents model fitting curve. (c) The dose-effect curve of parent SAX in T2DM rats. The arrow indicates that the efficacy of the drug shows a downward trend with the time of administration

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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