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Table 10 Parameters of the PD model of 5-OH SAX in T2DM rats (n = 3)

From: Pharmacokinetic/Pharmacodynamic modelling of Saxagliptin and its active metabolite, 5-hydroxy Saxagliptin in rats with Type 2 Diabetes Mellitus

Parameter

Units

Mean

SD

CV

EC50

ng/mL

251.74

97.31

38.65

Gam

 

1.31

0.26

20.10

E0

 

7.03

12.81

182.30

Emax

 

60.88

12.54

20.60

stdev0

 

1.97

0.15

7.79

  1. EC50 median effective concentration, Gam slope parameter of S-curve, Emax maximum effect of drug, stdev0 fitting residual error
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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