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Table 12 Parameters of the PD model of parent SAX in T2DM rats (n = 3)

From: Pharmacokinetic/Pharmacodynamic modelling of Saxagliptin and its active metabolite, 5-hydroxy Saxagliptin in rats with Type 2 Diabetes Mellitus

Parameter

Units

Mean

SD

CV

EC50

ng/mL

544.74

374.29

68.71

Gam

 

1.38

1.08

77.98

Emax

 

71.47

25.21

35.27

stdev0

 

2.01

0.95

47.57

  1. EC50 median effective concentration, Gam slope parameter of S-curve, Emax maximum effect of drug, stdev0 fitting residual error
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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