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Table 3 Intra-day and inter-day precision and accuracy of SAX and 5-OH SAX

From: Pharmacokinetic/Pharmacodynamic modelling of Saxagliptin and its active metabolite, 5-hydroxy Saxagliptin in rats with Type 2 Diabetes Mellitus

Analytes

Norminal concentration (ng/mL)

Intra-day (n = 5)

Inter-day (n = 5)

Measured

concentration (ng/mL)

Accuracy (%)

Precision (RSD, %)

Measured

concentration (ng/mL)

Accuracy (%)

Precision (RSD, %)

SAX

5

5.06

101.24

5.63

4.97

99.32

6.21

15

14.92

99.45

2.79

14.93

99.55

3.40

1000

1004.60

100.46

1.25

999.88

99.99

1.97

2000

2003.18

100.16

2.21

1985.63

99.28

3.01

5-OH SAX

1

1.06

106.20

7.43

1.03

103.00

9.11

3

3.01

100.47

3.88

3.16

105.47

6.71

200

200.93

100.46

1.82

203.78

101.89

3.71

400

402.18

100.55

1.10

400.21

100.05

4.21