Fig. 7

Compound 4c regulated cell cycle and FAS death receptor. A–D, cell cycle analysis of CRC celsl after 4c treatment using flow cytometry. E, F, 4c promoted cell cycle regulator MDM2 and p21. G, H, 4c suppressed cell cycle checkpoints cyclin A2 and cyclin B. I, J, 4c up-regulated the expression of FAS death receptor. Data were presented as mean ± SD. Statistically significant differences were indicated as *P < 0.05, **P < 0.01, ***P < 0.001