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Table 4 Cox-regression results for predictors of parasitemia during pregnancy

From: Pharmacokinetics of piperaquine and its association with intermittent malaria preventive therapy outcomes during pregnancy

Variable

Malaria during pregnancy

Univariate analysis

Multivariate analysis

Cumulative risk

n/N (%)

Hazard Ratio

(95% CI)

p-value

aHR

(95% CI)

p-value

Age (years)

33/400 (8.3)

0.99 (0.97 to 1.04)

0.88

  

Gravidity

33/400 (8.3)

0.82 (0.66 to 1.01)

0.06

0.81 (0.60 to 1.09)

0.17

Gestational age (weeks)

33/400 (8.3)

0.93 (0.83 to 1.03)

0.16

  

Weight (kg)

33/400 (8.3)

0.99 (0.97 to 1.03)

0.67

  

Day 7 PQ cutoff after the first IPTp dose

< 30 ng/mL

4/15 (26.7)

5.22 (1.70 to 16)

0.004

5.60 (1.81 to 17.33)

0.003

≥ 30 ng/mL

13/230 (5.7)

1 (Reference)

 

1 (Reference)

 

Day 7 PQ cutoff after the second IPTp dose

< 30 ng/mL

2/5 (40)

4.40 (0.94 to 20)

0.05

4.40 (0.94 to 20.53)

0.05

≥ 30 ng/mL

9/117 (7.7)

1 (Reference)

 

1 (Reference)

 
  1. 95% CI = 95% confidence interval; bolded p values indicate significant association; aHR = adjusted hazard ratio