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Table 3 Summary of whole brain serotonin and redox markers in FSL and FRL juvenile rats

From: Passively administered fluoxetine reaches the juvenile brain of FSL rats and reduces antioxidant defences, without altering serotonin turnover

Neurochemical markers

FRL

FSL

control

control

passive fluoxetine

5-HIAA (ng/g)

105.2 ± 16.4

95.06 ± 28.81

95.88 ± 11.90

5-HT (ng/g)

33.28 ± 5.40

34.07 ± 4.01

34.67 ± 2.86

GSH (µg/g)

32.62 ± 7.07

25.54 ± 5.92a)

18.22 ± 6.75b)

GSSG (µg/g)

163.30 ± 77.44

338.80 ± 106.7a)

384.10 ± 141.00b)

  1. Limits of detection were 3.90 ng/ml (5-HIAA and 5-HT), 0.31 µg/g (GSH) and 0.62 µg/g (GSSG). Final concentrations are expressed as w/w due to brain tissue being the sample matrix. The values used for calculations of the ratios are presented here as mean ± SD (n = 16 per group)
  2. a)statistically different (p < 0.05), compared to FRL control group
  3. b)statistically different (p < 0.05), compared to FSL fluoxetine group
  4. 5-HIAA 5-hydroxyindoleacetic acid. 5-HT 5-hydroxytryptamine. GSH Glutathione. GSSG glutathione disulphide
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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