Differential impact of pegfilgrastim, a recombinant human granulocyte colony stimulating factor, on the neutrophil count of male and female deer mice (Peromyscus maniculatus bairdii)

Table 1 Neutrophil and lymphocyte counts in male and female mice exposed to a single control or pegfilgrastim (0.1 or 1 mg/kg) subcutaneous injection at day two, four and seven post-administration

Day	Dose (mg/kg)	Sex	Neutrophils	Lymphocytes	NLR
2	0	M	24	75	0.320
		M	32	61	0.525
		M	32	64	0.500
		F	21	76	0.276
		F	14	82	0.171
		F	26	67	0.388
	0.1	M	33	61	0.541
		M	32	65	0.492
		M	23	71	0.324
		F	28	67	0.418
		F	26	68	0.382
		F	34	61	0.557
	1	M	28	68	0.412
		M	30	66	0.455
		M	29	64	0.453
		F	33	57	0.579
		F	32	63	0.508
		F	35	57	0.614
4	0	M	22	74	0.297
		M	13	84	0.155
		M	24	73	0.329
		F	15	82	0.183
		F	24	72	0.333
		F	17	78	0.218
	0.1	M	47	50	0.940
		M	32	65	0.492
		M	36	60	0.600
		F	38	59	0.644
		F	39	59	0.661
		F	34	61	0.557
	1	M	34	63	0.540
		M	22	72	0.306
		M	47	50	0.940
		F	53	44	1.205
		F	51	44	1.159
		F	50	47	1.064
7	0	M	13	86	0.151
		M	22	71	0.310
		M	17	78	0.218
		F	24	69	0.348
		F	15	83	0.181
		F	13	82	0.159
	0.1	M	36	60	0.600
		M	52	45	1.156
		M	30	64	0.469
		F	30	67	0.448
		F	24	75	0.320
		F	31	65	0.477
	1	M	13	86	0.151
		M	44	55	0.800
		M	44	54	0.815
		F	41	55	0.745
		F	46	48	0.958
		F	51	45	1.133

M male, F female, NLR neutrophil-lymphocyte ratio. Data representative of cell counts of up to 100 cells for each sample

ISSN: 2050-6511