Table 2 Descriptive statistics of pairwise comparisons (significant p-values or large Cohen’s d effect size values are highlighted in bold)

Dose × Day

Day 2 vs 4

Ctrl

0.36 ± 0.13 vs 0.25 ± 0.08

0.880

1.0

−2.205—0.222

Low

0.45 ± 0.09 vs 0.65 ± 0.15

0.185

1.6

0.206—2.836

High

0.50 ± 0.08 vs 0.87 ± 0.36

0.003

1.4

0.092—2.661

Day 2 vs 7

Ctrl

0.36 ± 0.13 vs 0.22 ± 0.08

0.587

1.2

−2.448—0.050

Low

0.45 ± 0.09 vs 0.58 ± 0.30

0.654

0.6

−0.590—1.729

High

0.50 ± 0.08 vs 0.77 ± 0.33

0.039

1.1

−0.147—2.310

Day 4 vs 7

Ctrl

0.25 ±.077 vs 0.22 ± 0.08

1.000

0.3

−1.452—0.828

Low

0.65 ± 0.15 vs 0.58 ± 0.30

1.000

0.5

−1.632—0.671

High

0.87 ± 0.36 vs 0.77 ± 0.33

1.000

0.3

−1.419—0.858

Ctrl vs Low

Day 2

0.36 ± 0.13 vs 0.45 ± 0.09

1.000

0.8

−0.419—1.943

Day 4

0.25 ± 0.08 vs 0.65 ± 0.15

0.001

3.3

1.418—5.025

Day 7

0.22 ± 0.08 vs 0.58 ± 0.30

0.004

1.6

0.258—2.918

Ctrl vs High

Day 2

0.36 ± 0.13 vs 0.50 ± 0.08

0.563

1.3

−0.020—2.492

Day 4

0.25 ± 0.08 vs 0.87 ± 0.36

< 0.001

2.4

0.798—3.838

Day 7

0.22 ± 0.08 vs 0.77 ± 0.33

< 0.001

2.2

0.706—3.675

Low vs High

Day 2

0.45 ± 0.09 vs 0.50 ± 0.08

1.000

0.6

−0.617—1.696

Day 4

0.65 ± 0.15 vs 0.87 ± 0.36

0.119

0.8

−0.413—1.951

Day 7

0.58 ± 0.30 vs 0.77 ± 0.33

0.225

0.6

−0.579—1.742

Dose × Sex

Female vs Male

Ctrl

0.25 ± 0.08 vs 0.31 ± 0.13

0.489

0.5

−0.423—1.460

Low

0.49 ± 0.12 vs 0.62 ± 0.26

0.130

0.6

−0.316—1.584

High

0.88 ± 0.28 vs 0.54 ± 0.26

< 0.001

1.3

−2.294— −0.245

Ctrl vs Low

Female

0.25 ± 0.09 vs 0.49 ± 0.11

0.018

2.4

1.118—3.582

Male

0.31 ± 0.13 vs 0.62 ± 0.26

0.002

1.5

0.449—2.575

Ctrl vs High

Female

0.25 ± 0.09 vs 0.88 ± 0.28

< 0.001

3.1

1.665—4.480

Male

0.31 ± 0.13 vs 0.54 ± 0.26

0.028

1.1

0.103—2.105

Low vs High

Female

0.50 ± 0.12 vs 0.88 ± 0.28

< 0.001

1.8

0.700—2.938

Male

0.62 ± 0.26 vs 0.54 ± 0.26

0.948

0.3

−1.253—0.608