Skip to main content
Fig. 6 | BMC Pharmacology and Toxicology

Fig. 6

From: Evaluation of the therapeutic potential of novel nanoparticle formulations of glutathione and virgin coconut oil in an experimental model of carbon tetrachloride-induced liver failure

Fig. 6

Immunohistochemical analysis revealed A the absence of NF-κB expression in the liver tissue of the control group. B CCl4 treatment significantly increased NF-κB expression in the cytoplasm and nucleus of hepatocytes, as indicated by brown staining (arrowhead). C and D CS and FO groups showing less increase in NF-κB immunostaining. E and F showing decrease of NFκB-P65 antibody within the hepatic cells in treated groups with GSH, and VCO. G, H treatment groups with Nano-GSH and Nano-VCO showed an obvious decrease in both cytoplasmic and nuclear expression of the NFκB-P65 antibody (arrowhead). I The combined treated group (O) showed a marked decrease in cytoplasmic and nuclear expression of the NFκB-P65 antibody (arrowhead). J The nano combined-treated group (Nano-O) showed a significant decrease in NFκB-P65 immunostaining within the hepatic cells (arrowheads). CCL4 carbon tetrachloride, CS chitosan, GSH glutathione, Fe3O4 ferric oxide, VCO virgin coconut oil

Back to article page

BMC Pharmacology and Toxicology

ISSN: 2050-6511

Contact us