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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Pulrodemstat, a selective inhibitor of KDM1A, suppresses head and neck squamous cell carcinoma growth by triggering apoptosis

Fig. 3

Pulrodemstat blunts DNA repair and replication to induce apoptosis. (A) The correlation between KDM1A transcripts and tumor proliferation signature were determined by TCGA database. (B) The correlation between KDM1A transcripts and DNA repair signature were determined by TCGA database. (C) The correlation between KDM1A transcripts and DNA replication signature were determined by TCGA database. (D) The role of Pulrodemstat in regulating HNSCC cell lines apoptosis were evaluated by flow cytometry. The p values in (A–C) were conducted using R software (The R Foundation for Statistical Computing, 2020)

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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