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Fig. 5 | BMC Pharmacology and Toxicology

Fig. 5

From: Pulrodemstat, a selective inhibitor of KDM1A, suppresses head and neck squamous cell carcinoma growth by triggering apoptosis

Fig. 5

TET3 serves as the upstream regulator of KDM1A. (A) The methylation levels of KDM1A in HNSCC was analyzed by TCGA database. (B, C) The correlation between KDM1A methylation levels and HNSCC clinical outcome were determined by TCGA database. (D) The correlation between LSD methylation levels and KDM1A transcripts were evaluated by TCGA database. (E) The correlation between TET3 and KDM1A were determined by TCGA database. (F) Hel1A, SCC-9, Cal-27, SCC-1 and FaDu cells were lysed and then subjected to IB analysis as indicated. Statistical analysis was conducted using R software, version v4.0.3. Results were considered statistically significant when the p-value was less than 0.05

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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