Table 2 Grade results
Certainty assessment | № of patients | Effect | Certainty | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Outcomes | № of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Ticagrelor | Clopidogrel | Relative | |
(95% CI) | |||||||||||
Mortality | 6 | RCT | Not serious | Not serious | Not serious | Not serious | None | 78/2480 (3.1%) | 91/2443 (3.7%) | RR 0.857 | ⨁⨁⨁⨁ |
(0.637 to 1.153) | High | ||||||||||
MI | 6 | RCT | Not serious | Not serious | Not serious | Not serious | Publication bias is strongly suspected | 49/2467 (2.0%) | 58/2470 (2.3%) | RR 0.680 | ⨁⨁⨁◯ |
(0.333 to 1.382) | Moderate | ||||||||||
Major Adverse Cardiovascular Events | 4 | RCT | Not serious | Not serious | Not serious | Not serious | None | 10/457 (2.2%) | 20/488 (4.1%) | RR 0.630 | ⨁⨁⨁⨁ |
(0.226 to 1.750) | High | ||||||||||
BARC | 7 | RCT | Not serious | Not serious | Not serious | Not serious | None | 48/2635 (1.8%) | 48/2637 (1.8%) | RR 1.020 | ⨁⨁⨁⨁ |
(0.651 to 1.595) | High | ||||||||||
TIMI Flow Grade Major | 5 | RCT | Not serious | Not serious | Not serious | Not serious | None | 135/2067 (6.5%) | 130/2032 (6.4%) | RR 1.020 | ⨁⨁⨁⨁ |
(0.860 to 1.201) | High | ||||||||||
Stroke | 5 | RCT | Not serious | Not serious | Not serious | Not serious | none | 29/2312 (1.3%) | 36/2276 (1.6%) | RR 0.830 | ⨁⨁⨁⨁ |
(0.508–1.348) | High | ||||||||||