Fig. 1
From: Toxicology study of a tissue anchoring paclitaxel prodrug
Structures and schematic of TRAP-paclitaxel. Overview of TRAPs technology. TRAP drugs are introduced into disease tissues and consist of a drug connected through a hydrolysable linker to an anchoring motif, which attaches the drug and linker to tissue extracellular matrix. Over time, the ester bonded linking paclitaxel to the succinic acid hydrolyzes, releasing active drugs to the tissue