Fig. 3

Minimal site reactivity upon intradermal injections of all treatment groups with Cremophor EL (CrEL) formulation. A Male and B female groups of saline, vehicle (10% CrEL, 10% EtOH, 80% D5W), paclitaxel (8 mg/mL), TRAP components (3.45 mg/mL sulfo-NHS and 1.77 mg/mL succinic anhydride), and TRAP-paclitaxel (20 mg/mL) were intradermally injected in a volume of 10 µL. Injection sites of mice receiving saline, vehicle, or paclitaxel were unremarkable. The formation of scabs and alopecia were observed in the TRAP and TRAP-PTX groups. Representative images from one mouse per group are shown. Mice were shaved on day 0 and again on days 21 and 27. Images are 1 cm x 1 cm