Fig. 5

Effect of L-carnitine (LCAR, 300 and 500 mg/kg/day, IP) on the hepatic expression of apoptotic-associated proteins caspase-3 and BCL2 in dexamethasone (DEXA)-toxified rats. A and B. Expressive images of IHC staining of liver sections against caspase-3 and BCl2, respectively (100× magnification; scale bar, 100 μm and 400× magnification in insets; scale bar, 50 μm). C and D. %areas of positive immunoexpression of caspase-3 and BCl2, respectively. Panel A and B. Insets display caspase3 and Bcl-2 immunostaining, respectively. Arrows refer to positive expressions. High power in the DEXA-LCAR300 group shows nuclear expression in invading neutrophils and lymphocytes (Thin arrow). Panel C and D. Data are shown as means ± SD, n = 6 per group; ^*,#,$,!P < 0.05 versus control, DEXA, DEXA-MET, and DEXA-LCAR300, respectively. BCl2, B-cell lymphoma-2