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Table 1 Effect of L-carnitine (LCAR, 300 and 500 mg/kg/day, IP) on general characteristics and serum hepatic function parameters in dexamethasone (DEXA)-toxified rats

From: L-carnitine attenuates autophagic flux, apoptosis, and necroptosis in rats with dexamethasone-induced non-alcoholic steatohepatitis

 

Control

DEXA

DEXA-MET

LCAR500

DEXA-LCAR300

DEXA-LCAR500

BW change (g)

3.50 ± 3.62

-82.00 ± 7.72*

-99.40 ± 10.71*#

4.83 ± 3.66

-77.67 ± 6.62*$

-83.00 ± 7.04*$

Liver index (%)

3.38 ± 0.04

6.22 ± 0.51*

4.68 ± 0.28*#

3.04 ± 0.14

5.40 ± 0.48*#$

5.35 ± 0.59*#

ALT (U/L)

55.00 ± 11.47

304.50 ± 91.90*

226.10 ± 19.63*

43.83 ± 12.54

222.00 ± 78.45*

152.30 ± 42.73*#

AST (U/L)

207.60 ± 20.66

379.30 ± 42.76*

325.40 ± 75.76*

157.70 ± 35.94

302.30 ± 69.95*

282.00 ± 44.20#

GGT (U/L)

18.83 ± 5.15

71.80 ± 12.25*

29.63 ± 6.28 #

16.22 ± 3.66

35.00 ± 11.05#

34.33 ± 13.41#

ALP (U/L)

547.30 ± 95.72

3381 ± 1062*

852.20 ± 214.2#

599.30 ± 165.50

1103 ± 251.4#

416.00 ± 49.82#

LDH (U/L)

1742 ± 517.40

5480 ± 1199*

3529 ± 1139*#

1623 ± 115

5331 ± 645.50*$

3477 ± 745.90*#!

Albumin (g/dL)

4.55 ± 0.22

3.21 ± 0.35 *

4.24 ± 0.47#

4.68 ± 0.21

4.19 ± 0.26#

4.33 ± 0.25#

Total bilirubin (mg/dL)

0.35 ± 0.05

0.96 ± 0.16*

0.37 ± 0.12#

0.19 ± 0.02

0.31 ± 0.15#

0.32 ± 0.08#

  1. Data are shown as means ± SD, n = 6 per group
  2. BW, body weight; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma-glutamyl transferase; ALP, alkaline phosphatase; LDH, lactate dehydrogenase
  3. *,#,$,!P < 0.05 versus control, DEXA, DEXA-MET, and DEXA-LCAR300 groups, respectively