Table 3 Signal strength of AEs of durvalumab at the PT level in FAERS database

Death*

1719

3.19

(3.01–3.37)

3.00

(1760.73)

1.31

(1.23)

2.48

(2.35)

Malignant neoplasm progression

882

1.17

(1.09–1.26)

1.16

(18.53)

0.19

(0.09)

1.14

(1.06)

Radiation pneumonitis*

704

56.06

(45.94–68.42)

54.10

(5096.23)

3.06

(2.89)

8.34

(6.84)

Pneumonitis*

540

3.41

(3.08–3.77)

3.34

(646.53)

1.43

(1.28)

2.69

(2.43)

Pneumonia

288

1.68

(1.48–1.91)

1.67

(66.28)

0.65

(0.46)

1.57

(1.38)

Dyspnoea

263

1.53

(1.35–1.75)

1.53

(41.12)

0.53

(0.34)

1.45

(1.27)

Pyrexia

236

0.85

(0.75–0.98)

0.85

(5.37)

-0.20

(-0.40)

0.87

(0.76)

Interstitial lung disease

233

1.28

(1.11–1.47)

1.28

(12.28)

0.31

(0.11)

1.24

(1.08)

Diarrhoea

232

0.82

(0.71–0.93)

0.82

(8.72)

-0.26

(-0.46)

0.83

(0.73)

Neutrophil count decreased

219

2.37

(2.04–2.75)

2.35

(134.46)

1.04

(0.82)

2.06

(1.78)

Metastases to central nervous system*

209

9.07

(7.47–11.01)

8.98

(730.39)

2.30

(2.02)

4.92

(4.06)

Febrile neutropenia

190

1.71

(1.46-2.00)

1.70

(46.16)

0.67

(0.43)

1.59

(1.36)

Fatigue

186

0.65

(0.56–0.75)

0.65

(32.33)

-0.56

(-0.78)

0.68

(0.58)

Rash

170

0.77

(0.66–0.90)

0.77

(10.98)

-0.34

(-0.57)

0.79

(0.67)

Platelet count decreased

163

1.35

(1.14–1.59)

1.34

(12.43)

0.38

(0.13)

1.30

(1.10)

Myelosuppression

152

1.83

(1.53–2.18)

1.82

(46.89)

0.75

(0.49)

1.68

(1.41)

Hepatic function abnormal

131

1.24

(1.03–1.49)

1.24

(5.43)

0.28

(0.01)

1.21

(1.01)

Pleural effusion

131

1.78

(1.47–2.15)

1.77

(36.92)

0.72

(0.44)

1.64

(1.36)

Cough

125

1.70

(1.40–2.05)

1.69

(29.64)

0.66

(0.37)

1.58

(1.30)

Hypothyroidism

121

0.76

(0.63–0.92)

0.76

(8.21)

-0.35

(-0.62)

0.78

(0.65)

Off label use

121

0.45

(0.38–0.54)

0.46

(75.84)

-1.05

(-1.31)

0.48

(0.40)

Asthenia

119

0.78

(0.64–0.94)

0.78

(6.92)

-0.33

(-0.60)

0.80

(0.66)

Nausea

116

0.63

(0.52–0.76)

0.63

(23.60)

-0.61

(-0.88)

0.66

(0.54)

Lung disorder*

113

2.54

(2.06–3.13)

2.53

(81.10)

1.13

(0.81)

2.18

(1.77)

Drug-induced liver injury*

112

3.83

(3.07–4.78)

3.81

(161.86)

1.56

(1.22)

2.96

(2.37)

Decreased appetite

111

0.60

(0.49–0.72)

0.60

(28.13)

-0.68

(-0.96)

0.62

(0.52)

Disease progression

110

0.80

(0.66–0.98)

0.80

(4.84)

-0.29

(-0.57)

0.82

(0.67)

Vomiting

109

0.91

(0.75–1.11)

0.91

(0.85)

-0.12

(-0.41)

0.92

(0.75)

Colitis

109

0.92

(0.75–1.12)

0.92

(0.69)

-0.11

(-0.40)

0.93

(0.76)

Anaemia

108

0.73

(0.60–0.89)

0.73

(9.94)

-0.41

(-0.70)

0.75

(0.62)