Fig. 2

Effects of paroxetine on markers of MI-induced cardiac injury. HW/BW ratio (A) as an indicator of cardiac hypertrophy. Serum levels of the cardiac injury biomarkers LDH (B), Tn-I (C), and CK-MB (D). Serum level of FGF23 as an indicator of cardiac remodeling (E). F H&E staining for cardiac muscle fascicles and fibers in the normal control group shows no inflammatory cell infiltration. The untreated (MI) group shows inflammatory cell infiltration, mainly histiocytes, with a few lymphocytes (black arrow) (20X power field). All data are expressed as means ± SEM. Differences between groups were determined using a one-way ANOVA followed by Dunnett’s post hoc test. The total number of biological and technical replicates is 6 per group. Statistically significant changes compared to the untreated MI rats are indicated with * (P < 0.05), ** (P < 0.01), *** (P < 0.001). Abbreviations C control, MI untreated myocardial infarction, P + MI myocardial infarction pre-treated with paroxetine, M + MI myocardial infarction pre-treated with metoprolol, R + MI myocardial infarction pre-treated with irbesartan