Fig. 5

Effects of paroxetine on inflammation. TNF-α (A) and serum level of CRP (B) for evaluation of inflammation. C PAS-stained cardiac tissue sections show positive macrophages (black arrows) (20X power field). All data are expressed as means ± SEM. Differences between groups were determined using one-way ANOVA followed by Dunnett’s post hoc test. The total number of biological and technical replicates is 6 per group. Statistically significant changes compared to untreated MI rats are indicated with ** (P < 0.01), *** (P < 0.001), or **** (P < 0.0001). Abbreviations C control, MI untreated myocardial infarction, P + MI myocardial infarction pre-treated with paroxetine, M + MI myocardial infarction pre-treated with metoprolol, R + MI myocardial infarction pre-treated with irbesartan