Fig. 6

Effect of paroxetine on VEGF and iNOS expression. The VEGF (A) and iNOS protein levels (B) (upper panel) and a representative immunoblot of the iNOS protein levels in the tissue homogenates of the left ventricle (lower panel) show the quantitative results of the immunoblot analysis. The iNOS protein expression was normalized to GAPDH, and the band densities were quantified using ImageJ software. The relative quantities are expressed in terms of the induced fold change. All data are expressed as means ± SEM (n = 4). Differences between groups were determined using a one-way ANOVA followed by Dunnett’s post hoc test. Statistically significant changes compared to the untreated MI rats are indicated with * (P < 0.05), *** (P < 0.001), or **** (P < 0.0001). Abbreviations C control, MI untreated myocardial infarction, P + MI myocardial infarction pre-treated with paroxetine, M + MI myocardial infarction pre-treated with metoprolol, R + MI myocardial infarction pre-treated with irbesartan