Table 3 The occurrence of TPMT and NUDT15 genetic variants
Patient Number | Gene | RefSNP accession ID number | Variant | CPIC Allele | CPIC Allele Clinical Functional Status | CPIC Phenotype Summary | Adverse events |
|---|---|---|---|---|---|---|---|
3 | NUDT15 | rs116855232 | c.415 C > T (p.Arg139Cys) | NUDT15*3 | No function | NUDT15 Intermediate Metabolizer | Mild leukopenia |
10 | NUDT15 | rs116855232 | c.415 C > T (p.Arg139Cys) | NUDT15*3 | No function | NUDT15 Intermediate Metabolizer | None |
11 | TPMT | rs75543815 | c.539 A > T (p.Tyr180Phe) | TPMT*6 | Uncertain function | TPMT Indeterminate Metabolizer | Withdrawal for severe leukopenia |
12 | NUDT15 | rs116855232 | c.415 C > T (p.Arg139Cys) | NUDT15*3 | No function | NUDT15 Intermediate Metabolizer | None |