Fig. 15

A Photomicrographs of H and E-stained liver sections from the control group. Liver sections from the control group show anastomosing hepatic cords (HC) radiating from the central vein (CV) and separated by blood sinusoids (S). The polygonal hepatocytes have eosinophilic cytoplasm and central rounded vesicular nuclei. (black arrows). Some hepatocytes are binucleated (yellow arrows). B liver sections from the diseased group show congested central veins (CV) and disorganization of the hepatic cords. Widespread vacuolated hepatocytes (arrows) with shrunken, irregular, and darkly stained pyknotic nuclei are noticed. C liver sections from the diseased group show congested hepatic portal veins (P) and widespread vacuolated hepatocytes (arrows) with shrunken, irregular, and darkly stained pyknotic nuclei. D liver sections from the diseased group show disorganization of the hepatic cords and widespread vacuolated hepatocytes (arrows) with shrunken, irregular, and darkly stained pyknotic nuclei. Severe mononuclear inflammatory cell infiltration (circles) appears close to the central vein (CV). E The liver section from the treated group shows regular anastomosing hepatic cords (HC) radiating from the central vein (CV) and separated by blood sinusoids (S). Most hepatocytes have eosinophilic cytoplasm and central rounded vesicular nuclei (yellow arrows). Some vacuolated hepatocytes (black arrows) with shrunken, irregular pyknotic nuclei are also detected. F The liver section from the treated group shows regular anastomosing of hepatic cords (HC) radiating from the central vein (CV) and separated by blood sinusoids (S). Most hepatocytes appear normal with eosinophilic cytoplasm and central rounded vesicular nuclei (yellow arrows). A few vacuolated hepatocytes (black arrows) with shrunken and irregular pyknotic nuclei were also detected. G the liver section from the best-treated group shows regular anastomosing hepatic cords (HC) radiating from the central vein (CV) and separated by blood sinusoids (S). Hepatocytes appear normal with eosinophilic cytoplasm and central rounded vesicular nuclei (yellow arrows). A few inflammatory cell infiltrations between hepatic cords are also noted