Table 2 Risk factors for tocilizumab-induced hypofibrinogenemia

Age ≥ 60 years

2.541(1.379 ~ 4.682)

0.003

Infection

2.659(1.508 ~ 4.690)

0.001

2.002(1.018 ~ 3.935)

0.044

COVID-19

4.717(1.866 ~ 11.921)

0.001

3.752(1.264 ~ 11.139)

0.017

CAR-T therapy

2.126(1.176 ~ 3.844)

0.013

4.409(2.017 ~ 9.635)

0.000

Blood transfusion

2.185(1.169 ~ 4.084)

0.014

Anticoagulants

2.332(1.357 ~ 4.010)

0.002

Antirheumatics

0.383(0.215 ~ 0.683)

0.001

0.451(0.227 ~ 0.894)

0.023

Glucocorticoids

2.732(1.168 ~ 6.387)

0.020

5.303(1.837 ~ 15.305)

0.002

Other drugs associated with HFIB

3.990(1.446 ~ 11.009)

0.008

Baseline fibrinogen

0.822(0.695 ~ 0.974)

0.023

0.813(0.670 ~ 0.988)

0.037

PT

1.152(1.001 ~ 1.326)

0.048