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Table 1 Baseline demographic and clinical characteristics among rivaroxaban, dabigatran and warfarin groups

From: Clinical effectiveness and safety comparison between direct oral anticoagulants and warfarin for nonvalvular atrial fibrillation patients following percutaneous left atrial appendage closure operation intervention: a prospective observational study

Baseline characteristics

Rivaroxaban

(n = 362)

Dabigatran

(n = 186)

Warfarin

(n = 126)

P

Age (y)

69.69 ± 8.11

69.91 ± 8.22

68.45 ± 8.71

0.280

Gender (Male, %)

57.7%

64.5%

59.5%

0.307

Stroke and bleeding risk factors

 CHF

1.1%

1.6%

2.4%

0.517

 Hypertension

61.6%

57.5%

55.6%

0.413

 Age > 75y

22.4%

26.9%

23.0%

0.491

 Diabetes mellitus

18.8%

21.0%

15.9%

0.528

 Stroke/TIA

45.9%

45.7%

42.9%

0.665

 Vascular disease

10.8%

13.4%

14.3%

0.480

 Age (65–74y)

53.6%

43.5%

48.4%

0.079

 Sex category (female gender)

42.3%

35.5%

40.5%

0.307

 Abnormal renal function

5.0%

3.8%

5.6%

0.733

 Abnormal liver function

2.2%

2.2%

3.2%

0.789

 Bleeding history

9.1%

10.2%

9.5%

0.917

 Drug interactions

37.3%

36.6%

46.0%

0.172

 Alcohol

7.2%

11.8%

7.1%

0.152

Coronary heart disease

17.1%

16.7%

14.3%

0.757

Watchman Size (mm)

27.11 ± 3.89

27.06 ± 3.93

27.31 ± 4.21

0.855

LVEF, %

47.37 ± 6.25

46.75 ± 6.25

48.17 ± 8.03

0.256

CHA2DS2-VASc score

3.08 ± 1.48

3.21 ± 1.57

3.17 ± 1.53

0.614

 3–4

45.9%

45.7%

46.0%

0.998

 ≥5

16.6%

21.0%

21.4%

0.313

HAS-BLED score

3.60 ± 1.18

3.56 ± 1.19

3.65 ± 1.14

0.816

 0–2

21.0%

20.4%

17.5%

0.692

 ≥3

79.0%

79.6%

82.5%

0.692

  1. Values are mean ± SD, n (%). P-value was calculated with two-way ANOVA analysis and represented with interaction, *P < 0.05
  2. CHF congestive heart failure, TIA transient ischemic attack, LVEF left ventricular ejection fraction; CHA2DS2-VASc risk calculated with risk factors congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, prior stroke or transient ischemic attack or thromboembolism, vascular disease, age 65–74 years, sex category; HAS-BLED risk score calculated with hypertension, abnormal renal or liver function, stroke, bleeding, labile international normalized ratio, elderly, drugs or alcohol