Table 11 Pharmacokinetic studies of pure EZ solution and combination of EZ and Piperine solution
Pharmacokinetic Parameters | EZ solution | Piperine solution | EZ and piperine solution |
|---|---|---|---|
Intercept | 1.278799 | 1.560009 | 1.820917 |
Slope | -0.03723 | -0.01811 | -0.02158 |
Co (mcg/mL) | 19.00198 | 36.30855 | 66.20892 |
K (hr-1) | 0.085744 | 0.041701 | 0.049706 |
Dose (mg) | 10 | 10 | 10 |
Dose (mcg) | 10,000 | 10,000 | 10,000 |
Vd (mL) | 526.261 ± 3.56 | 275.4172 ± 1.46 | 151.037 ± 1.62 |
Vd (L) | 0.526261 ± 0.25 | 0.275417 ± 0.26 | 0.151037 ± 0.95 |
t1/2 (hr) | 8.082205 ± 0.64 | 16.61823 ± 0.48* | 13.94199 ± 0.15** |
Cl (L/hr) | 45.12369 ± 1.62 | 11.48523 ± 0.16* | 7.507444 ± 0.33** |
AUC-o-t (mcg.hr/mL) | 4.875494 ± 0.52 | 9.202138 ± 0.95 | 16.67723 ± 1.42 |
AUC 1-t (mcg.hr/mL) | 202.0825 ± 0.16 | 573.825 ± 0.67 | 1053.75 ± 0.62 |
AUC 1-inf(mcg.hr/mL) | 29.03996 ± 0.82 | 323.2522 ± 1.35 | 391.5022 ± 0.54 |
AUC total (mcg.hr/mL) | 235.998 ± 3.74 | 906.2793 ± 2.48 | 1461.929 ± 2.34 |
Cmax (mcg.hr/mL) | 24.36 ± 0.62 | 61.25 ± 0.95 | 159.86 ± 1.46** |
Tmax (mL/min) | 1.95 ± 0.49 | 3.25 ± 0.18 | 4.36 ± 0.26* |