Table 1 Drug treatment and experimental protocol
From: Epoetin alfa has a potent anxiolytic effect on naive female rats
| Â | Experimental Schedule | |||||||
|---|---|---|---|---|---|---|---|---|
Experimental Groups | 0–7 Days | 8th Day | 15th Day | 22th Day | 29th Day | 30th Day | 31th Day | |
Control (C) (n = 8) | Adaptation | 1 ml/kg Saline (i.p.) | 1 ml/kg Saline (i.p.) | 1 ml/kg Saline (i.p.) | 1 ml/kg Saline (i.p.) | X | Euthanization | |
Epoetin alfa (EPOα) (n = 8) | 1000 U/kg EPOα (i.p.) | 1000 U/kg EPOα (i.p.) | 1000 U/kg EPOα (i.p.) | 1000 U/kg EPOα (i.p.) | x | Euthanization | ||
Epoetin alfa (EPOα) (n = 8) | 2000 U/kg EPOα (i.p.) | (2000). U/kg EPOα (i.p.) | 2000 U/kg EPOα (i.p.) | 2000 U/kg EPOα (i.p.) | x | Euthanization | ||
Injection Schedule | X | X | 9 pm | 9 pm | 9 pm | 9 pm | x | Â |
Behavioral Test Schedule | X | X | X | X | X | X | 9–12 pm: OFT + EPM 8 pm: LDB | |