In vivo toxicological evaluation of 3-benzylideneindolin-2-one: antifungal activity against clinical isolates of dermatophytes

Table 1 Antifungal activity of 3-benzylideneindolin-2-one against clinical isolates of dermatophytes (n = 30) from patients with superficial fungal infections

Clinical isolate	MIC				MFC
Clinical isolate	MIC range	GM MIC ± SEM	MIC50	MIC90	MFC range	GM MFC ± SEM	MFC50	MFC90
Trichophyton mentagrophytes (n = 18)	2–8	4.16 ± 0.59	4	8	4–32	14.81 ± 2.72	16	32
Trichophyton rubrum (n = 3)	4–8	6.35 ± 1.33	8	8	16	16.0 ± 0.00	16	16
Microsporum gypseum (n = 4)	4–8	5.66 ± 1.15	4	8	16–32	26.91 ± 4.00	32	32
Microsporum canis (n = 3)	4–8	5.04 ± 0.0	4	8	16–32	20.16 ± 5.33	16	32
Epidermophyton floccosum (n = 2)	0.25-1	0.5 ± 0.38	0.25	1	1–4	2.0 ± 1.50	1	4

Minimum inhibitory concentration (MIC): the lowest concentration (mg/L) of the compound that inhibited visible fungal growth
Minimum fungicidal concentration (MFC): the lowest concentration (mg/L) of the compound that killed at least 99.9% of the initial inoculums
Geometric mean: (GM); Standard error of mean: (SEM)
MIC50: the lowest concentration (mg/L) of the compound at which 50% of isolates are inhibited
MIC90: the lowest concentration (mg/L) of the compound at which 90% of isolates are inhibited
MFC50: the lowest concentration (mg/L) of the compound at which 50% of isolates are killed
MFC90: the lowest concentration (mg/L) of the compound at which 90% of isolates are killed

ISSN: 2050-6511