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Fig. 7 | BMC Pharmacology and Toxicology

Fig. 7

From: Melatonin protect against pregabalin-induced gonadotoxicity via anti-oxidative, anti-inflammatory, anti-apoptotic, enzymatic and hormonal regulatory mechanisms in rats

Fig. 7

Effect of Melatonin on the Histology of the Testes in Pregabalin-Exposed Male Wistar Rats. The Control and Melatonin Groups showed normal seminiferous tubules (black arrow) with germ cells (red arrow) at varying degrees of maturation. Mature sperm cells (red circle) were present in the lumens. In contrast, the Low-Dose Pregabalin Group exhibited distorted tubules (black arrow), sloughed germ cells (red arrow), and scanty mature sperm cells (red circle). However, the Pregabalin + Melatonin Groups showed improved histological features, with normal seminiferous tubules (black arrow) and Leydig cells

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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