Table 3 Mean pharmacokinetic parameters of prednisone and prednisolone in T and R formulations at fast or fed state

C_max (ng/mL)

118.05 ± 19.19

140.79 ± 28.00

23.59 ± 3.68

25.00 ± 3.48

109.35 ± 26.74

118.85 ± 17.45

20.26 ± 2.89

22.53 ± 3.19

AUC_0 − t(ng∙h/mL)

532.58 ± 97.57

621.19 ± 89.85

122.10 ± 17.22

136.91 ± 19.54

584.86 ± 77.53

666.30 ± 91.10

123.09 ± 14.28

138.23 ± 18.92

AUC_0−∞(ng∙h/mL)

553.61 ± 101.96

644.61 ± 98.29

128.98 ± 19.50

143.65 ± 21.63

630.41 ± 85.54

705.30 ± 104.27

134.09 ± 17.11

148.35 ± 21.13

t_1/2 (h)

2.30 ± 0.31

2.29 ± 0.28

2.32 ± 0.39

2.32 ± 0.29

2.72 ± 0.42

2.46 ± 0.29

2.79 ± 0.56

2.50 ± 0.28

T_max^* (h)

1.84(1.00 ~ 3.50)

1.00(0.50 ~ 2.00)

3.50(1.33 ~ 4.00)

3.00(1.67 ~ 3.50)

2.50(0.75 ~ 5.00)

1.67(0.25 ~ 5.00)

4.00(2.50 ~ 6.00)

3.52(2.50 ~ 5.00)