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Table 4 The GMR and 90% CI of prednisone and prednisolone in T and R formulations at fast or fed state

From: Food effects and pharmacokinetic evaluation of oral single-dose prednisone acetate and prednisolone in healthy Chinese subjects

Parameter

Fast (GMR)

Fed (GMR)

prednisolone

prednisone

prednisolone

prednisone

T

R

T/R

(%)

90%CI(%)

T

R

T/R

(%)

90%CI(%)

T

R

T/R

(%)

90%CI(%)

T

R

T/R

(%)

90%CI(%)

Cmax(ng/mL)

116.69

138.17

84.46

(80.30 ~ 88.83)

23.35

24.65

94.71

(89.55 ~ 100.16)

106.59

117.78

90.50

(84.06 ~ 97.43)

20.08

22.30

90.04

(87.11 ~ 93.08)

AUC0 − t (ng·h/mL)

521.40

609.52

85.54

(83.46 ~ 87.68)

120.75

134.78

89.59

(85.55 ~ 93.82)

580.27

661.77

87.68

(86.04 ~ 89.36)

122.31

137.10

89.22

(86.97 ~ 91.52)

AUC0 − inf(ng·h/mL)

541.22

631.44

85.71

(83.71 ~ 87.76)

127.24

141.21

90.11

(86.02 ~ 94.39)

625.41

699.95

89.35

(87.35 ~ 91.40)

132.37

147.11

89.98

(86.71 ~ 93.38)