Parameter | Fast (GMR) | Fed (GMR) | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
prednisolone | prednisone | prednisolone | prednisone | |||||||||||||
T | R | T/R (%) | 90%CI(%) | T | R | T/R (%) | 90%CI(%) | T | R | T/R (%) | 90%CI(%) | T | R | T/R (%) | 90%CI(%) | |
Cmax(ng/mL) | 116.69 | 138.17 | 84.46 | (80.30 ~ 88.83) | 23.35 | 24.65 | 94.71 | (89.55 ~ 100.16) | 106.59 | 117.78 | 90.50 | (84.06 ~ 97.43) | 20.08 | 22.30 | 90.04 | (87.11 ~ 93.08) |
AUC0 − t (ng·h/mL) | 521.40 | 609.52 | 85.54 | (83.46 ~ 87.68) | 120.75 | 134.78 | 89.59 | (85.55 ~ 93.82) | 580.27 | 661.77 | 87.68 | (86.04 ~ 89.36) | 122.31 | 137.10 | 89.22 | (86.97 ~ 91.52) |
AUC0 − inf(ng·h/mL) | 541.22 | 631.44 | 85.71 | (83.71 ~ 87.76) | 127.24 | 141.21 | 90.11 | (86.02 ~ 94.39) | 625.41 | 699.95 | 89.35 | (87.35 ~ 91.40) | 132.37 | 147.11 | 89.98 | (86.71 ~ 93.38) |