Table 1 Summary of four algorithms used for signals detection

ROR

ROR=ad/bc

ROR ≥ 2

95%CI = e^{ln(ROR)±1.96(1/a+1/b+1/c+1/d)∧0.5}

95%CI > 1

PRR

PRR = a(c + d)/(a + b)/c

PRR ≥ 2

χ2=[(ad-bc)∧2](a + b + c + d)/[(a + b)(c + d)(a + c)(b + d)]

χ2 ≥ 4

BCPNN

IC = log2[a(a + b + c + d)/(a + b)/(a + c)]

IC025 = e^{ln(IC)±1.96(1/a+1/b+1/c+1/d)∧0.5}

IC025 > 0

MGPS

EBGM = a(a + b + c + d)/[(a + b)(a + c)]

EBGM05 = e^{ln(EBGM)±1.64(1/a+1/b+1/c+1/d)∧0.5}

EBGM05 > 2