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Table 3 Significant safety signals on the SOC level

From: Comparison of serious adverse effects of methylphenidate, atomoxetine and amphetamine in the treatment of ADHD: an adverse event analysis based on the FAERS database

SOC

ROR(95χ CI)

PRR(c2)

IC(IC025)

EBGM(EBGM05)

Methylphenidate

Psychiatric disorders

4.47(4.4, 4.54)

3.7(45434.21)

1.88(1.86)

3.68(3.63)

Atomoxetine

Psychiatric disorders

5.44(5.34, 5.55)

4.29(36447.31)

2.1(2.07)

4.28(4.21)

Reproductive system and breast disorders

2.49(2.35, 2.64)

2.46(989.5)

1.29(1.21)

2.45(2.33)

Amphetamine

Psychiatric disorders

4.06(3.98, 4.15)

3.43(20570.27)

1.77(1.74)

3.42(3.36)

  1. Note foot ROR, reporting odds ratio; PRR, proportional reporting ratio; IC, information component; EBGM, Bayes geometric mean; ADR signal is significant if a ≥ 3, ROR or PRR ≥ 2.0 or IC025 > 0 or EBGM05 > 2 with a 95% confidence interval (95% CI) value of more than 1.0