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Fig. 2 | BMC Pharmacology and Toxicology

Fig. 2

From: Combination of 10-hydroxy-decanoic acid and ZnO nanoparticles abrogates lead acetate-induced nephrotoxicity in rats: targeting oxidative stress and inflammatory signalling

Fig. 2

The effect of different treatments on kidney lead content, antioxidant, and lipid peroxidation markers. a) Kidney’s lead content, b) MDA level, c) GSH level, and d) SOD and GST activities. Administration of lead acetate significantly increased renal Pb content, MDA, and GSH levels. This was accompanied by a marked reduction in SOD and GST enzymatic activities compared to the sham group. Treatment with 10-HDA and ZnONPs, either individually or in combination, effectively mitigated these alterations. Notably, the combined treatment demonstrated superior efficacy in enhancing SOD and GST activities, as well as restoring GSH levels, compared to the individual treatments. Values are shown as mean ± SD (n = 10). *P < 0.05 vs. sham, #P < 0.05 vs. PbAc-induced group, and aP < 0.05 vs. PbAc + Comb

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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