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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Combination of 10-hydroxy-decanoic acid and ZnO nanoparticles abrogates lead acetate-induced nephrotoxicity in rats: targeting oxidative stress and inflammatory signalling

Fig. 3

The effect of different treatments on the expression levels of renal inflammatory markers. a) Representative western blot images. b-d) Protein levels of renal Nrf2, HO-1, and p-IKK, respectively. e & f) Renal mRNA expression levels of IL-1β, IL-6, IL-8, and TNF-α. g) renal NO level. In the PbAc-induced group, a significant reduction in the protein levels of Nrf2 and HO-1 was observed compared to the sham group. Treatment with 10-HDA and ZnONPs, either individually or in combination, resulted in a marked increase in Nrf2 and HO-1 protein levels relative to the PbAc-induced rats. Furthermore, the combined treatment demonstrated greater efficacy in enhancing Nrf2 and HO-1 protein expression than the individual treatments. PbAc exposure triggered a strong inflammatory response in comparison to the sham group, as indicated by the elevated levels of kidney inflammatory mediators, including p-IKK protein level, the mRNA expression level of IL-1β, IL-6, IL-8, and TNF-α, as well as NO level. Treatment with 10-HDA and ZnONPs significantly reduced these proinflammatory markers in PbAc-induced rats. Values are shown as mean ± SD. *P < 0.05 vs. sham, #P < 0.05 vs. PbAc-induced group, and aP < 0.05 vs. PbAc + Comb

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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