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Table 2 The impact of different treatments on the serum kidney function parameters

From: Combination of 10-hydroxy-decanoic acid and ZnO nanoparticles abrogates lead acetate-induced nephrotoxicity in rats: targeting oxidative stress and inflammatory signalling

Investigational groups

BUN

(mg/dl)

Urea

(mg/dl)

Creatinine (mg/dl)

Cystatin C (mg/l)

Sham

11.6 ± 2.6

25.3 ± 2.5

0.40 ± 0.06

0.9 ± 0.27

10-HDA

11.5 ± 3.2

26.1 ± 2.9

0.38 ± 0.06

0.9 ± 0.26

ZnONPs

12.3 ± 1.9

24.7 ± 1.9

0.41 ± 0.08

0.8 ± 0.08

Comb

12.9 ± 1.7

26.1 ± 3.7

0.41 ± 0.01

0.9 ± 0.13

PbAc

17.1 ± 2.7*

37.0 ± 1.8*

1.10 ± 0.06*

2.1 ± 0.05*

PbAc + 10- HDA

16.8 ± 3.2*

36.0 ± 2.1* a

0.97 ± 0.09*a

1.9 ± 0.5* a

PbAc + ZnONPs

16.9 ± 1.1*

36.2 ± 1.9* a

0.96 ± 0.09*a

2.2 ± 0.4*a

PbAc + Comb

14.6 ± 3.09*#

30.1 ± 2.1*#

0.72 ± 0.05*#

1.3 ± 0.2#

  1. Values are shown as mean ± SD (n = 10). *P < 0.05 vs. sham, #P < 0.05 vs. PbAc-induced group, and aP < 0.05 vs. PbAc + Comb
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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