Fig. 9

(A): A photomicrograph of rat liver of control rats showing normal hepatic architecture. The hepatic lobules containing central vein (CV) and separated by blood sinusoids (BS). The cords of hepatocytes are lined by Kupffer cells (red arrow). (B): Photomicrograph of the liver of rats treated with olanzapine only showing dilated and congested portal vein (DCPV), and inflammatory infiltrate around (red arrow), proliferation of bile duct (black arrow), fibrosis (yellow arrow). (C): Photomicrograph of the liver of rats treated with olanzapine only (another filed) showing dilated and congested central vein (CV), some hepatocytes with hydropic degeneration (HD), many with vacuolated cytoplasm (V), some apoptotic cells (red arrow), red blood cells in dilated blood sinusoids (BS). (D): A photomicrograph of a liver section of rats treated with olanzapine and subjected to zinc at low dose showing the liver still have changes in the form of dilated and congested portal vein (DCPV) with thickening of wall (red arrow) and fibrosis. Singes of degeneration of liver cells such as karyorrhexis (black arrow), karyolysis (white arrow) and apoptosis (green arrow). (E): A photomicrograph of a liver section of rat treated with onlazapine and subjected to zinc at high dose showing substantial improvements as compared to group treated with olanzapine only, however, some liver cells appeared degenerated in the form apoptotic cells (yellow arrow), necrosis in foci of hepatocytes (N). Karyorrhexis (black arrow), karyolysis in some nuclei of hepatocytes (red arrow)