A disproportionality analysis of adverse events associated with loop diuretics in the FDA Adverse Event Reporting System (FAERS)

Table 1 Algorithms and thresholds for signal detection

Algorithms	Equation	Threshold
ROR	ROR = ad/bc 95%CI = e^{ln(ROR)±1.96(1/a+1/b+1/c+1/d)^0.5}	a ≥ 3 ROR >1 95%CI (lower limit) > 1
PRR	PRR = a (c + d)/c/ (a + b) χ² = [(ad − bc)²](a + b + c + d)/[(a + b)(c + d)(a + c)(b + d)]	a ≥ 3 PRR ≥ 2 95%CI (lower limit) > 1
BCPNN	IC = log₂a(a + b + c + d)(a + c)(a + b) 95% CI = e^{ln(IC)±1.96(1/a+1/b+1/c+1/d) ^ 0.5}	IC025 > 0
EBGM	EBGM = a(a + b + c + d)/(a + c)/(a + b) 95% CI = e^{ln(EBGM)±1.96(1/a+1/b+1/c+1/d)^0.5}	EBGM05 > 2

Notes: a, the number of reports that simultaneously include the suspect drug and the suspect adverse drug reaction; b, the number of reports that include the suspect adverse drug reaction but are related to other medications (excluding the drug of interest); c, number of reports containing the suspect drug with other adverse drug reactions (except the event of interest); d, number of reports containing other medications and other adverse drug reactions

ISSN: 2050-6511