Table 3 Signal strength of shared adverse events at the PT level for Furosemide, torsemide, and bumetanide
Preferred Term (PT) | Furosemide | Torsemide | Bumetanide | |||
|---|---|---|---|---|---|---|
N | ROR (95CI lower limit) | N | ROR (95CI lower limit) | N | ROR (95CI lower limit) | |
Metabolic alkalosis | 250 | 152.39(132.87) | 12 | 50.85(28.79) | 3 | 50.02(16.1) |
Hypovolaemia | 228 | 31.23(27.35) | 23 | 25.48(16.91) | 11 | 48.49(26.8) |
Hypokalaemia | 1646 | 29.89(28.44) | 143 | 20.92(17.73) | 25 | 14.38(9.69) |
Hyponatraemia | 1655 | 23.92(22.77) | 133 | 15.58(13.13) | 14 | 6.43(3.8) |
Hyperkalaemia | 962 | 22.56(21.15) | 78 | 14.9(11.92) | 18 | 13.59(8.55) |
Acute kidney injury | 3448 | 19.53(18.86) | 200 | 9.08(7.89) | 66 | 11.85(9.27) |
Orthostatic hypotension | 398 | 17.99(16.29) | 18 | 6.66(4.2) | 10 | 14.7(7.9) |
Pemphigoid | 142 | 16.82(14.24) | 15 | 14.63(8.81) | 3 | 11.5(3.71) |
Hypomagnesaemia | 252 | 14.9(13.15) | 12 | 5.84(3.32) | 11 | 21.27(11.76) |
Polyuria | 127 | 12.16(10.2) | 14 | 11.11(6.57) | 16 | 50.76(31.02) |
Electrolyte imbalance | 145 | 10.3(8.74) | 65 | 38.77(30.35) | 5 | 11.68(4.86) |
Blood urea increased | 191 | 8.48(7.35) | 12 | 4.43(2.51) | 13 | 19.18(11.12) |
Hypocalcaemia | 193 | 8.15(7.07) | 18 | 6.33(3.98) | 6 | 8.35(3.75) |
Cardiac failure acute | 63 | 7.69(6) | 8 | 8.15(4.07) | 5 | 20.13(8.37) |
Dehydration | 1216 | 7.17(6.78) | 230 | 11.44(10.03) | 39 | 7.62(0.55) |
Brain natriuretic peptide increased | 28 | 7.12(4.9) | 4 | 8.49(3.18) | 3 | 25.29(8.15) |
Syncope | 824 | 6.43(6) | 104 | 6.78(5.59) | 24 | 6.2(4.15) |
Hypotension | 1550 | 6.15(5.85) | 153 | 5.05(4.3) | 42 | 5.5(4.05) |
Cardiac failure | 614 | 6(5.54) | 83 | 6.79(5.47) | 17 | 5.5(3.41) |
Bradycardia | 383 | 5.52(4.99) | 60 | 7.24(5.62) | 10 | 4.77(2.56) |
Blood creatinine increased | 434 | 5.1(4.64) | 40 | 3.92(2.88) | 25 | 9.8(6.6) |
Renal impairment | 489 | 4.69(4.29) | 116 | 9.37(7.8) | 21 | 6.68(4.35) |
Glomerular filtration rate decreased | 63 | 4.4(3.43) | 7 | 4.09(1.95) | 3 | 6.94(2.23) |
Rash maculo-papular | 114 | 4.12(3.42) | 12 | 3.63(2.06) | 5 | 5.99(2.49) |
Fluid retention | 247 | 3.75(3.31) | 24 | 3.05(2.05) | 20 | 10.15(6.54) |
Oedema peripheral | 552 | 3.41(3.14) | 127 | 6.63(5.56) | 20 | 4.18(2.69) |
Pancreatitis acute | 86 | 3.08(2.49) | 15 | 4.51(2.72) | 6 | 7.21(3.24) |
Right ventricular failure | 29 | 3.03(2.1) | 5 | 4.38(1.82) | 4 | 13.9(5.21) |