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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Effects of adenosine triphosphate, thiamine pyrophosphate, melatonin, and liv-52 on subacute pyrazinamide proliferation hepatotoxicity in rats

Fig. 3

(A-F) Histological appearances of liver tissues of HG (A), PZG (B), APZG (C), TPZG (D), MPZG (E), and LPZG (F) groups (Hematoxylin-eosin staining). A: Normal histological appearance of liver tissue. B: Severe hydropic degeneration (arrowhead) and necrosis (arrow) in liver tissue. HG; healthy group, PZG; pyrazinamide group. C: Moderate hydropic degeneration (arrowhead) and necrosis (arrow) appearance in liver tissue. D: Moderate hydropic degeneration (arrowhead) and necrosis (arrow) appearance in liver tissue. E: Moderate hydropic degeneration (arrowhead) and necrosis (arrow) appearance in liver tissue. F: Mild hydropic degeneration (arrowhead) and necrosis (arrow) appearance in liver tissue. HG; healthy group, PZG; pyrazinamide group, APZG; adenosine triphosphate + pyrazinamide group, TPZG; thiamine pyrophosphate + pyrazinamide group, MPZG; melatonin + pyrazinamide group, LPZG; Liv-52 + pyrazinamide group

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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