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Table 1 Analysis of histopathological and immunohistochemical analyses results in liver tissues

From: Effects of adenosine triphosphate, thiamine pyrophosphate, melatonin, and liv-52 on subacute pyrazinamide proliferation hepatotoxicity in rats

Experimental groups

Histopathological analyses

Immunohistochemical analysis

Hydropic degeneration

Necrosis

Caspase 3

Median (Quartile1 - Quartile3)

Mean ± Standart deviation

HG

0 (0–0)

0 ± 0

0 (0–0)

0 ± 0

0 (0–0)

0.17 ± 0.38

PZG

3 (3–3)*

2.83 ± 0.38

3 (3–3)*

2.56 ± 0.50

3 (2–3)*

2.67 ± 0.48

APZG

2 (2–2)**,#

1.64 ± 0.49

2 (1–2)**,#

1.64 ± 0.49

2 (1–2)**

1.75 ± 0.55

TPZG

2 (2–2)**,#

2.00 ± 0.34

2 (2–2)**,#

1.83 ± 0.38

2 (2–2)**,#

2.00 ± 0.48

MPZG

2 (1–2)**

1.56 ± 0.50

2 (1.25-2)**,#

1.75 ± 0.44

2 (2–2)**

1.86 ± 0.49

LPZG

1 (1–1)**

1.00 ± 0.41

1 (1–1)**

0.83 ± 0.38

1 (1–2)**

1.36 ± 0.54

  1. Grading (0–3): 0; absent, 1; mild, 2; moderate, 3; severe. *; p < 0.001 vs. HG, **; p < 0.05 vs. PZG, #; p < 0.05 vs. LPZG. HG; healthy group, PZG; pyrazinamide group, APZG; adenosine triphosphate + pyrazinamide group, TPZG; thiamine pyrophosphate + pyrazinamide group, MPZG; melatonin + pyrazinamide group, LPZG; Liv-52 + pyrazinamide group. Kruskal-Wallis test was used for statistical analysis, followed by post hoc Dunn’s test