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Table 2 General characteristics of reports with faricimab from the FAERS and JADER database

From: Safety profile of faricimab: a multi-source pharmacovigilance analysis using FAERS and JADER

Characteristics

FAERS

JADER

 

Number

Proportion (%)

Number

Proportion (%)

Number of events

4234

142

Gender

 Female

1707

40.3

53

37.3

 Male

1524

36

78

54.9

 Missing

1003

23.7

11

7.7

Weight

 <50 kg

17

0.4

4

2.8

 50–80 kg

196

4.6

28

19.6

 >80 kg

135

3.2

1

0.7

 Missing

3886

91.8

109

76.8

Age

 <18 years

93

2.2

–

–

 18–40 years

70

1.7

–

–

 41–60 years

483

11.4

11

7.7

 61–80 years

1332

31.5

81

57

 ≥81 years

563

13.3

40

28.2

 Missing

1693

40

10

7

Occupation

 Medical doctor

2478

58.5

137

96.5

 Consumer

1401

33.1

1

0.7

 Health Professional

271

6.4

1

0.7

 Pharmacist

77

1.8

3

2.1

 Missing

7

0.2

0

0

Report country

 United States

2167

51.2

–

–

 India

333

7.9

–

–

 Japan

284

6.7

142

100

 Canada

232

5.5

–

–

 France

175

4.1

–

–

 United Kingdom

173

4.1

–

–

 Australia

140

3.3

–

–

 Korea, South

121

2.9

–

–

 Germany

90

2.1

–

–

 South Africa

59

1.4

–

–

Outcome

 Hospitalization

170

4

–

–

 Death

129

3

5

3.5

 Disability

52

1.2

–

–

 Life-threatening

17

0.4

–

–

 Required Intervention

5

0.1

–

–

Outcome

 Congenital anomaly

2

0

–

–

 Partially Recovered

–

–

40

28.2

 Recovered

–

–

37

26.1

 Not Recovered

–

–

35

24.6

 Sequelae Present

–

–

6

4.2

 Other

639

15.1

–

–

 Missing

1014

23.9

19

13.4

Indications(top five)

 Neovascular age-related macular degeneration

1354

32

83

58.5

 Product used for unknown indication

879

20.8

–

–

 Diabetic retinal oedema

603

14.2

39

27.5

 Age-related macular degeneration

225

5.3

17

12

 Retinal vein occlusion

202

4.8

1

0.7

 Polypoidal choroidal vasculopathy

–

–

2

1.4