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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Can vildagliptin protect against radiation-induced premature ovarian failure? Insights into the AMPK and AKT signaling pathways

Fig. 3

Effect of vildagliptin co-administration on radiation-induced histological alterations of the ovarian tissue using H & E staining. (A) Control ovaries showing normal histological architecture, ovarian follicles in various stages of development (black arrows) (x 200). (B) Ovaries from vilda-alone treated rats showing normal histological architecture, ovarian follicles in various stages of development (black arrows) (x 200). (C) Irradiated ovaries showing hyperplasia of ovarian connective tissue, marked dilatation of ovarian blood vessels, and leukocytic infiltration (blue arrows) (x 200). (D) Irradiated ovaries showing pyknosis and degradation of granulosa cell layers of graafian follicles and disorganization of internal thecal layer (red arrows) (x 400). (E) Ovaries from IR + vilda rats where mild oedema of interstitial tissue and mild congestion of ovarian blood vessels were observed (black asterisk) (x 200). (F) Ovaries from IR + vilda showing a mature graafian follicle with a centrally-located oocyte and normal organization of granulosa cells (red asterisk) (x 400)

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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