Can vildagliptin protect against radiation-induced premature ovarian failure? Insights into the AMPK and AKT signaling pathways

Table 1 Effect of vildagliptin co-administration on change in body weight and GSI in radiation-induced POF

Group	Control	Radiation	Radiation + Vilda	Vilda alone
Change in body weight (gm)	39.5 ± 7.9	21.3 ± 4.4^a	28.7 ± 6.9^{a, b}	40.4 ± 9.1^b
GSI (%)	0.078 ± 0.015	0.063 ± 0.009^a	0.057 ± 0.014^a	0.056 ± 0.017^a

a. Female rats were subjected to a single dose of 3.2 Gy whole-body γ-radiation, and/or vildagliptin (10 mg/kg/day, orally) for 13 consecutive days
b. Data are presented as mean ± S.D (n = 15)
c. a; significantly different from the control group at p < 0 0.05, b; significantly different from radiation group at p < 0 0.05, using one-way ANOVA followed by Tukey-Kramer as a post-hoc test

ISSN: 2050-6511