Fig. 3

Box plot of the duration of drug-drug interaction clinical trials. Boxplots show the median (horizontal line), interquartile range (boxes), and data range (whiskers). Median values are labeled above each box. Group comparisons were performed using the Mann-Whitney U test, indicating no statistically significant difference between 2013–2019 and 2020–2022 groups (p = 0.13, Wilcoxon r = 0.18). Sample sizes: 2013–2019 (n = 82), 2020–2022 (n = 63)