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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Kaempferol inhibits cardiomyocyte pyroptosis via promoting O-GlcNAcylation of GSDME and improved acute myocardial infarction

Fig. 3

Kaempferol promoted OGT-mediated O-GlcNAcylation in H/R-treated cardiomyocytes. (A) Following different treatments, western blot was conducted to detect O-GlcNAcylation level and the expression of OGT and OGA. (B-D) Molecular docking results confirmed the strong hydrogen bonding between Kaempferol and OGT. (E, F) SPR analysis was performed to verify the binding between Kaempferol and OGT. CON, control; H/R, hypoxia/reoxygenation; Kae, Kaempferol; SPR, Surface plasmon resonance. **P < 0.01. *P < 0.05. ns: no significance

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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